This injectable combination is used for:

Peripheral neuropathy

Diabetic neuropathy

Alcoholic neuropathy

Sciatica

Neuralgia

Nutritional deficiencies

Anemia associated with B-complex vitamin deficiency

Supportive therapy in neuritis

Adjunct in tuberculosis or antiepileptic therapy causing B vitamin depletion

Route: Intramuscular (IM) or slow Intravenous (IV) injection

Dose:

Typically 1 ampoule once daily or as advised by the physician.

Frequency and duration depend on clinical severity and response.

Common (usually mild):

Pain at injection site

Mild nausea

Rash or itching

Red urine (due to B12)

Rare but serious:

Allergic reactions

(anaphylaxis)

Skin eruptions

Dizziness or headache

Hepatotoxicity (rare, with excessive Niacinamide)

Peripheral vascular collapse (extremely rare)

Pregnancy & Lactation: Usually safe but must be prescribed.

Kidney/Liver Impairment: Use cautiously.

Drug interactions:

Isoniazid and hydralazine can deplete B6 levels.

Chloramphenicol may inhibit B12 metabolism.

Alcohol use diminishes efficac

Store in a cool, dry place (15–25°C).

Protect from light.

Do not freeze.

Use the lowest effective dose for the shortest possible duration.

Monitor liver and kidney function during prolonged use.

Use cautiously in elderly patients and those with cardiovascular risk factors.

Not recommended for self-injection; should be administered by a healthcare professional.

Store below 25°C

Protect from light and moisture

Do not freeze

Monitoring

Blood pressure (especially in hypertensive patients)

Kidney and liver function (with long-term use)

Signs of GI bleeding or cardiovascular events

Advantages vs. Traditional NSAIDs

Lower risk of gastric ulcers and bleeding

Once-daily dosing

Good for long-term arthritis management in select patients

Disadvantages

Higher cost

Increased cardiovascular risk compared to non-selective NSAIDs

Not suitable for patients with heart disease

Storage

Store at room temperature (15–30°C), away from moisture and heat:

Keep out of reach of children

Important Notes

Use lowest effective dose for the shortest possible duration

Not for use as a first-line analgesic in general pain or fever

Always take under medical advice